AirHint found the following cheapest return flights from Rio Negro (MDE) to Santiago (SCL) in December 2025 (see full year).

Return flights

07 Dec - 09 Dec	JetSmart
12 Dec - 01 Jan	JetSmart
05 Dec - 09 Dec	JetSmart
07 Dec - 12 Dec	JetSmart
04 Dec - 09 Dec	JetSmart
01 Dec - 09 Dec	JetSmart
12 Dec - 02 Jan	JetSmart
12 Dec - 31 Dec	JetSmart
29 Dec - 16 Jan	JetSmart	direct
22 Dec - 07 Jan	JetSmart
05 Dec - 19 Dec	JetSmart	direct
12 Dec - 30 Dec	JetSmart
29 Dec - 19 Jan	JetSmart
03 Dec - 09 Dec	JetSmart
01 Dec - 03 Dec	JetSmart
22 Dec - 01 Jan	JetSmart
13 Dec - 01 Jan	JetSmart
01 Dec - 30 Jan	JetSmart	direct
22 Dec - 05 Jan	JetSmart
28 Dec - 07 Jan	JetSmart

Also check the deals for one-way flights from Rio Negro to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Santiago in December from 280€

Return flights