AirHint found the following cheapest return flights from Rio Negro (MDE) to Santiago (SCL) in December 2025 (see full year).

Return flights

30 Dec - 11 Jan	JetSmart
11 Dec - 01 Jan	JetSmart
30 Dec - 04 Jan	JetSmart
31 Dec - 11 Jan	JetSmart
25 Dec - 11 Jan	JetSmart	direct
29 Dec - 11 Jan	JetSmart	direct
30 Dec - 01 Jan	JetSmart
24 Dec - 11 Jan	JetSmart
26 Dec - 11 Jan	JetSmart	direct
28 Dec - 11 Jan	JetSmart	direct
05 Dec - 09 Dec	JetSmart
07 Dec - 09 Dec	JetSmart
11 Dec - 25 Dec	JetSmart
05 Dec - 11 Dec	JetSmart
07 Dec - 11 Dec	JetSmart
05 Dec - 08 Dec	JetSmart	direct
07 Dec - 08 Dec	Avianca
01 Dec - 09 Dec	JetSmart
11 Dec - 16 Dec	JetSmart
05 Dec - 12 Dec	JetSmart

Also check the deals for one-way flights from Rio Negro to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Santiago in December from 300€

Return flights