AirHint found the following cheapest return flights from Rio Negro (MDE) to Santiago (SCL) in December 2025 (see full year).

Return flights

27 Dec - 02 Jan	Avianca
29 Dec - 02 Jan	Avianca
29 Dec - 05 Jan	Avianca
29 Dec - 31 Dec	JetSmart
28 Dec - 03 Jan	Avianca
27 Dec - 03 Jan	Avianca
29 Dec - 19 Jan	LATAM Airlines Group
28 Dec - 31 Dec	JetSmart
29 Dec - 17 Jan	JetSmart
31 Dec - 07 Jan	Avianca
29 Dec - 07 Jan	Avianca
28 Dec - 07 Jan	Avianca
30 Dec - 31 Dec	JetSmart
29 Dec - 30 Dec	JetSmart
28 Dec - 30 Dec	JetSmart
28 Dec - 30 Dec	JetSmart	direct
27 Dec - 31 Dec	JetSmart
27 Dec - 29 Dec	JetSmart
27 Dec - 30 Dec	JetSmart
27 Dec - 28 Dec	JetSmart

Also check the deals for one-way flights from Rio Negro to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rio Negro to Santiago in December from 420€

Return flights