AirHint found the following cheapest return flights from Rio Negro (MDE) to Guatemala City (GUA) in December 2025 (see full year).
Return flights
| 29 Dec - 10 Jan | Copa | ||
| 30 Dec - 02 Jan | LATAM Airlines Group | ||
| 31 Dec - 04 Jan | Copa | ||
| 30 Dec - 08 Jan | Aeromexico | ||
| 31 Dec - 08 Jan | Aeromexico |
Also check the deals for one-way flights from Rio Negro to Guatemala City in December.
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