AirHint found the following cheapest return flights from Orlando (MCO) to Panama City (PTY) in December 2025 (see full year).

Return flights

06 Dec - 08 Dec	Avianca
08 Dec - 10 Dec	Avianca
10 Dec - 12 Dec	Avianca
09 Dec - 11 Dec	Avianca
09 Dec - 12 Dec	Avianca
30 Dec - 14 Jan	Spirit Airlines
07 Dec - 14 Dec	Avianca
09 Dec - 17 Dec	Avianca
18 Dec - 22 Dec	Spirit Airlines
06 Dec - 13 Dec	Spirit Airlines
13 Dec - 15 Dec	Spirit Airlines
27 Dec - 08 Jan	Copa	direct
28 Dec - 01 Jan	Copa	direct
30 Dec - 10 Jan	Spirit Airlines
30 Dec - 10 Jan	Copa	direct
30 Dec - 06 Jan	Frontier Airlines
17 Dec - 06 Jan	Spirit Airlines
30 Dec - 05 Jan	Spirit Airlines
18 Dec - 06 Jan	jetBlue
27 Dec - 05 Jan	Spirit Airlines

Also check the deals for one-way flights from Orlando to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Orlando to Panama City in December from 366€

Return flights