AirHint found the following cheapest return flights from Orlando (MCO) to Panama City (PTY) in December 2025 (see full year).

Return flights

08 Dec - 09 Dec	Copa	direct
02 Dec - 09 Dec	Spirit Airlines
14 Dec - 18 Dec	Copa	direct
28 Dec - 01 Jan	Copa	direct
27 Dec - 01 Jan	Copa	direct
02 Dec - 09 Dec	Copa	direct
17 Dec - 07 Jan	Spirit Airlines
29 Dec - 02 Jan	Spirit Airlines
19 Dec - 04 Jan	Spirit Airlines
28 Dec - 02 Jan	Spirit Airlines
28 Dec - 02 Jan	Copa	direct
29 Dec - 02 Jan	Copa	direct
19 Dec - 04 Jan	Copa	direct
20 Dec - 04 Jan	Copa	direct

Also check the deals for one-way flights from Orlando to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Orlando to Panama City in December from 352€

Return flights