AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in October 2025 (see full year).

Return flights

23 Oct - 30 Oct	Avianca
23 Oct - 14 Nov	Avianca
31 Oct - 27 Nov	Avianca
31 Oct - 30 Nov	Avianca
31 Oct - 29 Nov	Avianca
10 Oct - 23 Oct	Avianca
01 Oct - 17 Oct	Avianca
01 Oct - 28 Oct	Avianca
09 Oct - 21 Oct	Avianca
08 Oct - 22 Oct	Avianca
08 Oct - 23 Oct	Avianca
03 Oct - 28 Oct	Avianca
10 Oct - 09 Nov	Avianca
20 Oct - 10 Nov	Avianca
09 Oct - 12 Oct	Avianca
10 Oct - 13 Oct	Avianca
21 Oct - 30 Nov	Avianca
24 Oct - 15 Nov	Avianca
22 Oct - 04 Nov	Avianca
19 Oct - 02 Nov	Avianca

Also check the deals for one-way flights from Madrid to Santa Cruz in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in October from 764€

Return flights