AirHint found the following cheapest return flights from Madrid (MAD) to Santa Cruz (VVI) in October 2025 (see full year).

Return flights

10 Oct - 24 Oct	Avianca
09 Oct - 02 Nov	Avianca
27 Oct - 27 Nov	Air Europa	direct
15 Oct - 13 Nov	Air Europa	direct
08 Oct - 23 Oct	Air Europa	direct
13 Oct - 23 Oct	Air Europa	direct
10 Oct - 14 Oct	Avianca
27 Oct - 08 Nov	Air Europa	direct
25 Oct - 08 Nov	Air Europa	direct
18 Oct - 28 Oct	Air Europa	direct
03 Oct - 19 Oct	Avianca
10 Oct - 26 Oct	Avianca
26 Oct - 22 Nov	Avianca
19 Oct - 13 Nov	Avianca
24 Oct - 12 Nov	Avianca
15 Oct - 25 Oct	Boliviana de Aviacion	direct
10 Oct - 27 Oct	Avianca
24 Oct - 11 Nov	Avianca
05 Oct - 21 Oct	Avianca
22 Oct - 01 Nov	Avianca

Also check the deals for one-way flights from Madrid to Santa Cruz in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santa Cruz in October from 763€

Return flights