AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in October 2025 (see full year).

Return flights

06 Oct - 24 Oct	Delta
06 Oct - 26 Oct	Delta
21 Oct - 28 Oct	Delta
21 Oct - 29 Oct	Delta
29 Oct - 16 Nov	Delta
29 Oct - 12 Nov	Delta
06 Oct - 14 Oct	Delta
06 Oct - 19 Oct	Delta
06 Oct - 20 Oct	Delta
06 Oct - 21 Oct	Delta
06 Oct - 28 Oct	Delta
13 Oct - 26 Oct	Delta
30 Oct - 06 Nov	Delta
27 Oct - 23 Nov	Delta
08 Oct - 23 Nov	Delta
26 Oct - 03 Nov	Delta
21 Oct - 18 Nov	Delta
23 Oct - 07 Nov	Delta
23 Oct - 23 Nov	Delta
23 Oct - 09 Nov	Delta

Also check the deals for one-way flights from Madrid to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in October from 700€

Return flights