AirHint found the following cheapest return flights from Madrid (MAD) to Santiago (SCL) in October 2025 (see full year).

Return flights

15 Oct - 27 Oct	Delta
15 Oct - 28 Oct	Delta
23 Oct - 09 Nov	Delta
23 Oct - 26 Nov	Delta
22 Oct - 02 Nov	Delta
15 Oct - 02 Nov	Delta
23 Oct - 02 Nov	Delta
22 Oct - 03 Nov	Delta
23 Oct - 03 Nov	Delta
22 Oct - 08 Nov	Delta
22 Oct - 06 Nov	Delta
22 Oct - 28 Nov	Delta
23 Oct - 28 Oct	Delta
15 Oct - 29 Oct	Delta
23 Oct - 29 Oct	Delta
22 Oct - 26 Oct	Delta
23 Oct - 26 Oct	Delta
15 Oct - 22 Oct	Delta
15 Oct - 23 Oct	Delta
20 Oct - 27 Oct	Avianca

Also check the deals for one-way flights from Madrid to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Santiago in October from 721€

Return flights