AirHint found the following cheapest return flights from Madrid (MAD) to Istanbul (SAW) in September 2025 (see full year).

Return flights

24 Sep - 07 Oct	Wizz Air Malta
08 Sep - 23 Sep	Wizz Air Malta
04 Sep - 30 Sep	Pegasus Airlines
24 Sep - 30 Sep	easyJet
19 Sep - 23 Sep	Ryanair
10 Sep - 30 Sep	easyJet
10 Sep - 23 Sep	easyJet
04 Sep - 16 Sep	Pegasus Airlines
23 Sep - 30 Sep	easyJet
17 Sep - 23 Sep	Ryanair
26 Sep - 30 Sep	Wizz Air Malta
04 Sep - 01 Oct	Pegasus Airlines
26 Sep - 04 Oct	Wizz Air Malta
29 Sep - 05 Oct	Wizz Air Malta
21 Sep - 12 Oct	Wizz Air
25 Sep - 05 Oct	Wizz Air Malta
29 Sep - 06 Oct	Wizz Air Malta
27 Sep - 11 Oct	Ryanair
24 Sep - 06 Oct	Ryanair
12 Sep - 01 Oct	easyJet

Also check the deals for one-way flights from Madrid to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Istanbul

Cheap car rent in Istanbul

Cheapest return flights from Madrid to Istanbul in September from 144€

Return flights