AirHint found the following cheapest return flights from Madrid (MAD) to Guatemala City (GUA) in September 2025 (see full year).

Return flights

16 Sep - 23 Sep	United
10 Sep - 20 Sep	United
04 Sep - 15 Sep	Lufthansa
23 Sep - 04 Oct	United
21 Sep - 15 Oct	United
08 Sep - 15 Sep	United
09 Sep - 16 Sep	United
14 Sep - 02 Oct	United
05 Sep - 14 Sep	United
15 Sep - 22 Sep	TAP
28 Sep - 05 Oct	United
22 Sep - 03 Oct	TAP
23 Sep - 03 Oct	TAP
02 Sep - 14 Oct	TAP
18 Sep - 01 Oct	TAP
29 Sep - 16 Oct	United
22 Sep - 26 Sep	TAP
15 Sep - 25 Sep	United
10 Sep - 19 Sep	TAP
02 Sep - 07 Oct	Avianca

Also check the deals for one-way flights from Madrid to Guatemala City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guatemala City in September from 555€

Return flights