AirHint found the following cheapest return flights from Madrid (MAD) to Guatemala City (GUA) in September 2025 (see full year).

Return flights

25 Sep - 30 Sep	United
24 Sep - 30 Sep	United
23 Sep - 23 Oct	United
30 Sep - 05 Oct	United
26 Sep - 11 Oct	United
25 Sep - 05 Oct	United
25 Sep - 28 Sep	United
23 Sep - 01 Oct	United
22 Sep - 29 Sep	TAP
19 Sep - 28 Sep	Avianca
22 Sep - 28 Sep	TAP
19 Sep - 21 Sep	Avianca
22 Sep - 03 Oct	TAP
29 Sep - 08 Oct	WORLD2FLY
18 Sep - 01 Oct	Avianca
24 Sep - 11 Oct	United
20 Sep - 04 Oct	WORLD2FLY
16 Sep - 22 Sep	TAP
19 Sep - 27 Sep	Avianca
18 Sep - 21 Sep	Avianca

Also check the deals for one-way flights from Madrid to Guatemala City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Madrid to Guatemala City in September from 600€

Return flights