AirHint found the following cheapest return flights from Lisbon (LIS) to Sao Tome (TMS) in December 2025 (see full year).

Return flights

28 Dec - 11 Jan	Turkish Airlines
28 Dec - 09 Jan	Turkish Airlines
10 Dec - 30 Jan	Ryanair
09 Dec - 30 Jan	TAAG Angola Airlines
11 Dec - 30 Jan	TAAG Angola Airlines
14 Dec - 30 Jan	TAAG Angola Airlines
30 Dec - 14 Jan	TAAG Angola Airlines
01 Dec - 08 Dec	Royal Air Maroc
06 Dec - 20 Dec	TAP	direct
13 Dec - 17 Jan	TAP	direct
13 Dec - 21 Dec	TAP
12 Dec - 30 Jan	Ryanair
26 Dec - 04 Jan	Turkish Airlines
15 Dec - 28 Dec	Ryanair
13 Dec - 20 Dec	TAP	direct
15 Dec - 21 Dec	Ryanair
27 Dec - 27 Dec	TAP	direct
12 Dec - 26 Dec	TAP
14 Dec - 29 Dec	TAAG Angola Airlines
16 Dec - 29 Dec	TAAG Angola Airlines

Also check the deals for one-way flights from Lisbon to Sao Tome in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Lisbon to Sao Tome in December from 976€

Return flights