AirHint found the following cheapest return flights from Lisbon (LIS) to Prague (PRG) in October 2025 (see full year).

Return flights

22 Oct - 20 Nov	easyJet	direct
22 Oct - 18 Nov	easyJet	direct
22 Oct - 04 Nov	Wizz Air Malta
22 Oct - 25 Nov	easyJet	direct
25 Oct - 03 Nov	Wizz Air Malta
25 Oct - 04 Nov	Wizz Air Malta
20 Oct - 18 Nov	Ryanair
22 Oct - 11 Nov	easyJet	direct
23 Oct - 03 Nov	Wizz Air Malta
15 Oct - 20 Nov	easyJet	direct
22 Oct - 29 Oct	easyJet
22 Oct - 28 Oct	Wizz Air Malta
25 Oct - 28 Oct	Wizz Air Malta
24 Oct - 28 Oct	Ryanair
22 Oct - 27 Oct	Wizz Air Malta
15 Oct - 28 Oct	Ryanair
24 Oct - 31 Oct	Ryanair
22 Oct - 28 Oct	easyJet	direct
27 Oct - 29 Oct	easyJet
27 Oct - 28 Oct	easyJet

Also check the deals for one-way flights from Lisbon to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Lisbon to Prague in October from 159€

Return flights