AirHint found the following cheapest return flights from Los Angeles (LAX) to Santiago (SCL) in October 2025 (see full year).

Return flights

07 Oct - 14 Oct	Frontier Airlines
16 Oct - 23 Oct	Frontier Airlines
23 Oct - 30 Oct	Frontier Airlines
19 Oct - 26 Oct	Frontier Airlines
05 Oct - 12 Oct	Frontier Airlines
02 Oct - 09 Oct	Frontier Airlines
08 Oct - 15 Oct	Copa
21 Oct - 28 Oct	Frontier Airlines
20 Oct - 27 Oct	Frontier Airlines
15 Oct - 22 Oct	Frontier Airlines
14 Oct - 10 Nov	Avianca
24 Oct - 01 Nov	Delta
15 Oct - 11 Nov	Frontier Airlines
27 Oct - 01 Nov	United

Also check the deals for one-way flights from Los Angeles to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Los Angeles to Santiago in October from 595€

Return flights