AirHint found the following cheapest return flights from Santorini (Thira) (JTR) to Istanbul (IST) in September 2025 (see full year).

Return flights

30 Sep - 04 Oct	Aegean Airlines	direct
30 Sep - 07 Oct	Aegean Airlines	direct
21 Sep - 30 Sep	SKY express
21 Sep - 23 Sep	SKY express
14 Sep - 30 Sep	SKY express
14 Sep - 16 Sep	SKY express
14 Sep - 20 Sep	SKY express
14 Sep - 23 Sep	SKY express
21 Sep - 06 Oct	SKY express
21 Sep - 04 Oct	SKY express
21 Sep - 01 Oct	SKY express
14 Sep - 04 Oct	SKY express
14 Sep - 01 Oct	SKY express
14 Sep - 22 Sep	SKY express
07 Sep - 16 Sep	SKY express
07 Sep - 12 Sep	SKY express
07 Sep - 20 Sep	SKY express
21 Sep - 03 Oct	SKY express
21 Sep - 10 Oct	SKY express
21 Sep - 09 Oct	SKY express

Also check the deals for one-way flights from Santorini (Thira) to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santorini (Thira) to Istanbul in September from 183€

Return flights