AirHint found the following cheapest return flights from Santorini (Thira) (JTR) to Istanbul (IST) in October 2025 (see full year).

Return flights

04 Oct - 07 Oct	Aegean Airlines	direct
01 Oct - 04 Oct	Aegean Airlines
05 Oct - 06 Oct	SKY express
05 Oct - 18 Oct	SKY express
05 Oct - 24 Oct	SKY express
12 Oct - 18 Oct	SKY express
12 Oct - 24 Oct	SKY express
05 Oct - 21 Oct	SKY express
05 Oct - 10 Oct	SKY express
05 Oct - 09 Oct	SKY express
26 Oct - 03 Nov	SKY express
26 Oct - 11 Nov	SKY express
26 Oct - 02 Nov	SKY express

Also check the deals for one-way flights from Santorini (Thira) to Istanbul in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Santorini (Thira) to Istanbul in October from 158€

Return flights