AirHint found the following cheapest return flights from New York (JFK) to Santiago (SCL) in September 2025 (see full year).

Return flights

16 Sep - 07 Oct	Frontier Airlines
25 Sep - 08 Oct	Frontier Airlines
09 Sep - 16 Sep	Avianca
13 Sep - 20 Sep	Frontier Airlines
10 Sep - 17 Sep	jetBlue
26 Sep - 09 Oct	Avianca
08 Sep - 30 Sep	jetBlue
12 Sep - 20 Sep	Frontier Airlines
12 Sep - 19 Sep	Avianca
26 Sep - 09 Oct	LATAM Airlines Group	direct
13 Sep - 20 Sep	Delta	direct
12 Sep - 20 Sep	Delta	direct
11 Sep - 18 Sep	Delta	direct
09 Sep - 16 Sep	Delta	direct

Also check the deals for one-way flights from New York to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from New York to Santiago in September from 496€

Return flights