AirHint found the following cheapest return flights from Istanbul (IST) to Prague (PRG) in October 2025 (see full year).

Return flights

07 Oct - 11 Oct	Wizz Air UK
11 Oct - 15 Oct	Wizz Air UK
01 Oct - 08 Oct	Wizz Air UK
07 Oct - 09 Oct	Wizz Air UK
08 Oct - 10 Oct	Wizz Air UK
04 Oct - 09 Oct	Wizz Air UK
08 Oct - 15 Oct	Pegasus Airlines	direct
06 Oct - 09 Oct	Pegasus Airlines	direct
07 Oct - 10 Oct	Pegasus Airlines	direct
10 Oct - 15 Oct	Wizz Air UK
22 Oct - 11 Nov	SKY express
22 Oct - 06 Nov	SKY express
25 Oct - 11 Nov	SKY express
25 Oct - 06 Nov	SKY express
20 Oct - 06 Nov	SKY express
29 Oct - 01 Nov	Fly One
24 Oct - 11 Nov	Fly One
24 Oct - 06 Nov	Fly One
17 Oct - 06 Nov	Fly One
28 Oct - 02 Nov	Pegasus Airlines

Also check the deals for one-way flights from Istanbul to Prague in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Prague

Cheap car rent in Prague

Cheapest return flights from Istanbul to Prague in October from 112€

Return flights