AirHint found the following cheapest return flights from Istanbul (IST) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

17 Sep - 05 Oct	Air France
08 Sep - 29 Sep	KLM
09 Sep - 30 Sep	KLM
10 Sep - 30 Sep	KLM
18 Sep - 29 Sep	KLM
18 Sep - 30 Sep	KLM
18 Sep - 25 Sep	KLM
16 Sep - 24 Sep	KLM
17 Sep - 24 Sep	Air France
17 Sep - 25 Sep	Air France
16 Sep - 26 Sep	Air Europa
17 Sep - 02 Oct	Air France
30 Sep - 08 Oct	Air Europa
29 Sep - 20 Oct	KLM
27 Sep - 04 Oct	KLM
01 Sep - 01 Oct	Air Europa
17 Sep - 05 Oct	Turkish Airlines	direct
17 Sep - 02 Oct	Turkish Airlines	direct
29 Sep - 20 Oct	Turkish Airlines	direct

Also check the deals for one-way flights from Istanbul to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Sao Paulo in September from 702€

Return flights