AirHint found the following cheapest return flights from Istanbul (IST) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

13 Sep - 25 Sep	KLM
06 Sep - 26 Sep	KLM
30 Sep - 07 Oct	KLM
19 Sep - 29 Sep	KLM
16 Sep - 30 Sep	KLM
16 Sep - 24 Sep	KLM
24 Sep - 30 Sep	KLM
15 Sep - 29 Sep	KLM
15 Sep - 30 Sep	KLM
10 Sep - 25 Sep	KLM
02 Sep - 25 Sep	KLM
03 Sep - 10 Oct	KLM
01 Sep - 01 Oct	KLM
17 Sep - 10 Oct	KLM
20 Sep - 04 Oct	British Airways
20 Sep - 03 Oct	British Airways
26 Sep - 05 Oct	British Airways
26 Sep - 04 Oct	British Airways
25 Sep - 04 Oct	British Airways
03 Sep - 10 Oct	Turkish Airlines	direct

Also check the deals for one-way flights from Istanbul to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Sao Paulo in September from 690€

Return flights