AirHint found the following cheapest return flights from Istanbul (IST) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

02 Dec - 09 Dec	KLM
30 Dec - 25 Jan	Air Europa
30 Dec - 26 Jan	Air Europa
07 Dec - 14 Dec	KLM
05 Dec - 13 Dec	British Airways
25 Dec - 26 Jan	KLM
02 Dec - 31 Dec	Air Europa
29 Dec - 19 Jan	Air Europa
30 Dec - 12 Jan	Air Europa
29 Dec - 11 Jan	Air Europa
27 Dec - 31 Dec	Air Europa
28 Dec - 19 Jan	Air Europa
06 Dec - 10 Jan	Qatar Airways
15 Dec - 30 Dec	Air Europa
15 Dec - 31 Dec	Air Europa
13 Dec - 23 Dec	Air Europa
12 Dec - 21 Dec	Turkish Airlines	direct
05 Dec - 13 Dec	Turkish Airlines	direct
31 Dec - 06 Jan	Air Europa
23 Dec - 17 Jan	Turkish Airlines	direct

Also check the deals for one-way flights from Istanbul to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Sao Paulo in December from 670€

Return flights