AirHint found the following cheapest return flights from Istanbul (IST) to Sao Paulo (GRU) in December 2025 (see full year).

Return flights

02 Dec - 06 Dec	Air Europa
01 Dec - 15 Dec	Air Europa
23 Dec - 23 Jan	Air Europa
29 Dec - 12 Jan	Air Europa
23 Dec - 18 Jan	Air Europa
08 Dec - 22 Dec	Air Europa
25 Dec - 01 Jan	Air Europa
28 Dec - 09 Jan	Air Europa
18 Dec - 28 Dec	Air Europa
17 Dec - 28 Dec	Air Europa
08 Dec - 22 Dec	Turkish Airlines	direct
01 Dec - 15 Dec	Turkish Airlines	direct
25 Dec - 04 Jan	Turkish Airlines	direct
17 Dec - 28 Dec	Turkish Airlines	direct
15 Dec - 03 Jan	Turkish Airlines	direct
23 Dec - 18 Jan	Turkish Airlines	direct
19 Dec - 26 Dec	Air Europa
16 Dec - 20 Dec	Air Europa
17 Dec - 04 Jan	Air Europa
15 Dec - 04 Jan	Air Europa

Also check the deals for one-way flights from Istanbul to Sao Paulo in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Sao Paulo in December from 748€

Return flights