AirHint found the following cheapest return flights from Istanbul (IST) to Sao Paulo (GRU) in October 2025 (see full year).

Return flights

05 Oct - 17 Oct	Qatar Airways
01 Oct - 09 Oct	KLM
03 Oct - 23 Oct	KLM
01 Oct - 28 Oct	KLM
01 Oct - 21 Oct	KLM
19 Oct - 26 Oct	Qatar Airways
02 Oct - 15 Oct	KLM
23 Oct - 09 Nov	Air Europa
01 Oct - 08 Oct	KLM
09 Oct - 22 Oct	KLM
22 Oct - 29 Oct	KLM
30 Oct - 16 Nov	KLM
22 Oct - 22 Nov	KLM
27 Oct - 10 Nov	Air Europa
27 Oct - 23 Nov	KLM
08 Oct - 04 Nov	KLM
06 Oct - 03 Nov	Air Europa
01 Oct - 07 Nov	Air Europa
10 Oct - 02 Nov	KLM
31 Oct - 12 Nov	Air Europa

Also check the deals for one-way flights from Istanbul to Sao Paulo in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Sao Paulo in October from 741€

Return flights