AirHint found the following cheapest return flights from Istanbul (IST) to Rome (FCO) in September 2025 (see full year).

Return flights

25 Sep - 30 Sep	Wizz Air UK
24 Sep - 25 Sep	Pegasus Airlines
22 Sep - 24 Sep	Pegasus Airlines
23 Sep - 30 Sep	Pegasus Airlines
26 Sep - 02 Oct	Wizz Air
27 Sep - 02 Oct	Pegasus Airlines
25 Sep - 02 Oct	AJet
23 Sep - 01 Oct	Pegasus Airlines
16 Sep - 25 Sep	Wizz Air UK
24 Sep - 01 Oct	Wizz Air UK
19 Sep - 24 Sep	Wizz Air UK
11 Sep - 17 Sep	AJet
10 Sep - 25 Sep	Pegasus Airlines
11 Sep - 11 Sep	AJet
11 Sep - 16 Sep	AJet
27 Sep - 08 Oct	Pegasus Airlines
20 Sep - 01 Oct	Pegasus Airlines
19 Sep - 01 Oct	Pegasus Airlines	direct
01 Sep - 10 Oct	Pegasus Airlines
23 Sep - 01 Oct	AJet	direct

Also check the deals for one-way flights from Istanbul to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Istanbul to Rome in September from 114€

Return flights