AirHint found the following cheapest return flights from Istanbul (IST) to Rome (FCO) in September 2025 (see full year).

Return flights

25 Sep - 30 Sep	AJet
27 Sep - 11 Oct	AJet
23 Sep - 21 Oct	Pegasus Airlines
15 Sep - 15 Oct	AJet
29 Sep - 04 Oct	Pegasus Airlines
25 Sep - 29 Sep	AJet
16 Sep - 18 Sep	Wizz Air
26 Sep - 29 Sep	Pegasus Airlines
23 Sep - 25 Sep	Wizz Air
09 Sep - 17 Sep	Pegasus Airlines
19 Sep - 26 Sep	Wizz Air UK
26 Sep - 28 Sep	Wizz Air
27 Sep - 02 Oct	AJet
27 Sep - 01 Oct	AJet
19 Sep - 23 Sep	Wizz Air UK
21 Sep - 28 Sep	Pegasus Airlines
28 Sep - 05 Oct	Fly One
28 Sep - 26 Oct	Wizz Air UK
27 Sep - 03 Oct	AJet
27 Sep - 05 Oct	AJet

Also check the deals for one-way flights from Istanbul to Rome in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rome

Cheap car rent in Rome

Cheapest return flights from Istanbul to Rome in September from 125€

Return flights