AirHint found the following cheapest return flights from Houston (HOU) to Sao Paulo (GRU) in September 2025 (see full year).

Return flights

07 Sep - 11 Sep	Spirit Airlines
15 Sep - 29 Sep	Spirit Airlines
06 Sep - 13 Sep	Spirit Airlines
27 Sep - 05 Oct	Spirit Airlines
11 Sep - 15 Sep	Spirit Airlines
27 Sep - 09 Oct	Spirit Airlines
27 Sep - 08 Oct	Spirit Airlines
27 Sep - 04 Oct	Spirit Airlines
09 Sep - 16 Sep	Spirit Airlines
28 Sep - 11 Oct	Spirit Airlines
16 Sep - 30 Sep	United
17 Sep - 01 Oct	United
18 Sep - 02 Oct	United
22 Sep - 06 Oct	United
23 Sep - 07 Oct	United
25 Sep - 09 Oct	United
14 Sep - 28 Sep	United
13 Sep - 27 Sep	United	direct
02 Sep - 16 Sep	United	direct
01 Sep - 15 Sep	United

Also check the deals for one-way flights from Houston to Sao Paulo in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Houston to Sao Paulo in September from 411€

Return flights