AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

10 Sep - 19 Sep	Copa
10 Sep - 13 Sep	Copa
20 Sep - 26 Sep	Copa
15 Sep - 20 Sep	Copa
02 Sep - 05 Sep	Copa
08 Sep - 12 Sep	Copa
15 Sep - 19 Sep	Copa
11 Sep - 14 Sep	Copa
10 Sep - 12 Sep	Copa
26 Sep - 28 Sep	Copa
26 Sep - 01 Oct	Copa
29 Sep - 01 Oct	Copa
28 Sep - 02 Oct	Copa
30 Sep - 28 Oct	Copa
26 Sep - 01 Oct	Avianca	direct
29 Sep - 03 Oct	Avianca	direct

Also check the deals for one-way flights from Guayaquil to Rio Negro in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Rio Negro in September from 224€

Return flights