AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in September 2025 (see full year).

Return flights

29 Sep - 01 Oct	Avianca
29 Sep - 03 Oct	Avianca	direct
21 Sep - 26 Sep	Avianca
27 Sep - 30 Sep	Avianca
29 Sep - 01 Oct	Avianca	direct
22 Sep - 29 Sep	Avianca
21 Sep - 07 Oct	Avianca
20 Sep - 24 Sep	Avianca
20 Sep - 15 Oct	Avianca
20 Sep - 27 Sep	Avianca
22 Sep - 17 Oct	Avianca
26 Sep - 01 Oct	Copa
26 Sep - 03 Oct	Copa
22 Sep - 25 Sep	LATAM Airlines Group
20 Sep - 26 Sep	Avianca
19 Sep - 15 Oct	Copa
23 Sep - 30 Sep	LATAM Airlines Group
19 Sep - 21 Sep	Avianca
19 Sep - 15 Oct	Avianca	direct
19 Sep - 28 Sep	Avianca

Also check the deals for one-way flights from Guayaquil to Rio Negro in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rio Negro

Cheap car rent in Rio Negro

Cheapest return flights from Guayaquil to Rio Negro in September from 227€

Return flights