AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in December 2025 (see full year).

Return flights

12 Dec - 15 Dec	Copa
12 Dec - 31 Dec	Copa
01 Dec - 05 Dec	Avianca	direct
26 Dec - 31 Dec	Avianca
03 Dec - 05 Dec	Avianca
01 Dec - 08 Dec	Avianca
24 Dec - 30 Dec	Avianca
02 Dec - 07 Dec	Avianca
25 Dec - 30 Dec	Avianca
25 Dec - 28 Dec	Avianca
31 Dec - 07 Jan	Avianca	direct
29 Dec - 14 Jan	Avianca
30 Dec - 06 Jan	Avianca
30 Dec - 05 Jan	Copa
31 Dec - 05 Jan	Copa
31 Dec - 02 Jan	Copa
26 Dec - 02 Jan	Avianca
31 Dec - 04 Jan	Avianca
30 Dec - 04 Jan	Avianca
28 Dec - 04 Jan	Avianca

Also check the deals for one-way flights from Guayaquil to Rio Negro in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Rio Negro in December from 238€

Return flights