AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

01 Oct - 04 Oct	Copa
01 Oct - 15 Oct	Copa
01 Oct - 29 Oct	Copa
23 Oct - 29 Oct	Copa
08 Oct - 15 Oct	Copa
02 Oct - 07 Oct	Copa
01 Oct - 09 Oct	Copa
03 Oct - 06 Oct	Avianca
17 Oct - 20 Oct	Avianca
27 Oct - 31 Oct	Avianca	direct
30 Oct - 02 Nov	Copa
28 Oct - 03 Nov	Copa
31 Oct - 07 Nov	Avianca
31 Oct - 03 Nov	Copa
30 Oct - 03 Nov	LATAM Airlines Group
31 Oct - 05 Nov	Copa

Also check the deals for one-way flights from Guayaquil to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Rio Negro

Cheap car rent in Rio Negro

Cheapest return flights from Guayaquil to Rio Negro in October from 224€

Return flights