AirHint found the following cheapest return flights from Guayaquil (GYE) to Rio Negro (MDE) in October 2025 (see full year).

Return flights

15 Oct - 17 Oct	Avianca	direct
01 Oct - 06 Oct	Avianca	direct
17 Oct - 20 Oct	Avianca	direct
27 Oct - 12 Nov	Avianca	direct
02 Oct - 06 Oct	Avianca
07 Oct - 10 Oct	Avianca
01 Oct - 09 Oct	Avianca
17 Oct - 19 Oct	Avianca
16 Oct - 20 Oct	Avianca
01 Oct - 04 Oct	Avianca
02 Oct - 07 Oct	Avianca
29 Oct - 05 Nov	Avianca
29 Oct - 03 Nov	Copa
31 Oct - 07 Nov	Copa
31 Oct - 05 Nov	Copa
30 Oct - 02 Nov	Avianca
30 Oct - 03 Nov	Copa
31 Oct - 03 Nov	Copa

Also check the deals for one-way flights from Guayaquil to Rio Negro in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Rio Negro in October from 232€

Return flights