AirHint found the following cheapest return flights from Guayaquil (GYE) to Madrid (MAD) in September 2025 (see full year).

Return flights

30 Sep - 22 Oct	Avianca
29 Sep - 29 Oct	Avianca
29 Sep - 06 Oct	Avianca
22 Sep - 30 Sep	Avianca
21 Sep - 25 Sep	Avianca
29 Sep - 02 Oct	Avianca
27 Sep - 27 Oct	Avianca
21 Sep - 28 Sep	Avianca
29 Sep - 16 Oct	Avianca
27 Sep - 28 Oct	Avianca
28 Sep - 04 Oct	Avianca
28 Sep - 05 Oct	Avianca
30 Sep - 05 Oct	Avianca
20 Sep - 29 Sep	LATAM Airlines Group
23 Sep - 30 Sep	Avianca
20 Sep - 26 Sep	LATAM Airlines Group
20 Sep - 30 Sep	LATAM Airlines Group
20 Sep - 27 Sep	LATAM Airlines Group
20 Sep - 28 Sep	LATAM Airlines Group
25 Sep - 30 Sep	LATAM Airlines Group

Also check the deals for one-way flights from Guayaquil to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Madrid in September from 818€

Return flights