AirHint found the following cheapest return flights from Guayaquil (GYE) to Madrid (MAD) in October 2025 (see full year).

Return flights

29 Oct - 10 Nov	Iberia
29 Oct - 16 Nov	Air Europa	direct
06 Oct - 26 Oct	Avianca
10 Oct - 17 Oct	jetBlue
02 Oct - 15 Nov	jetBlue
22 Oct - 21 Nov	Iberia	direct
01 Oct - 15 Nov	Avianca
12 Oct - 05 Nov	Avianca
03 Oct - 16 Nov	Copa
29 Oct - 09 Nov	Air Europa	direct
05 Oct - 24 Oct	Avianca
17 Oct - 25 Nov	LATAM Airlines Group
15 Oct - 05 Nov	Avianca
15 Oct - 29 Oct	Avianca
12 Oct - 25 Oct	Avianca
12 Oct - 27 Oct	Avianca
22 Oct - 31 Oct	Iberia	direct
12 Oct - 27 Oct	Iberia	direct
08 Oct - 22 Oct	Avianca
17 Oct - 27 Oct	Iberia	direct

Also check the deals for one-way flights from Guayaquil to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guayaquil to Madrid in October from 729€

Return flights