AirHint found the following cheapest return flights from Guatemala City (GUA) to Santiago (SCL) in December 2025 (see full year).

Return flights

22 Dec - 28 Dec	Copa
10 Dec - 17 Dec	Volaris Costa Rica
26 Dec - 12 Jan	Copa
23 Dec - 29 Dec	Copa
21 Dec - 28 Dec	Copa
21 Dec - 29 Dec	Copa
09 Dec - 23 Dec	Copa
20 Dec - 27 Dec	Copa
27 Dec - 11 Jan	Avianca
26 Dec - 03 Jan	Copa
19 Dec - 10 Jan	Copa
22 Dec - 30 Dec	Avianca
23 Dec - 30 Dec	Avianca
27 Dec - 02 Jan	Copa
17 Dec - 20 Dec	Avianca
25 Dec - 04 Jan	Avianca
27 Dec - 03 Jan	Copa

Also check the deals for one-way flights from Guatemala City to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Guatemala City to Santiago in December from 495€

Return flights