AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in September 2025 (see full year).

Return flights

14 Sep - 17 Sep	Avianca
02 Sep - 05 Sep	Avianca
09 Sep - 16 Sep	Avianca
25 Sep - 28 Sep	Avianca
05 Sep - 07 Sep	Avianca
23 Sep - 27 Sep	Avianca
15 Sep - 22 Sep	Avianca
28 Sep - 04 Oct	Avianca
21 Sep - 27 Sep	Avianca
17 Sep - 22 Sep	Avianca
14 Sep - 21 Sep	Avianca

Also check the deals for one-way flights from Guatemala City to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in September from 255€

Return flights