AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in December 2025 (see full year).

Return flights

10 Dec - 24 Dec	Copa
13 Dec - 16 Dec	Avianca
11 Dec - 15 Dec	Avianca
02 Dec - 05 Dec	Avianca
12 Dec - 16 Dec	Avianca
11 Dec - 14 Dec	Avianca
02 Dec - 06 Dec	Avianca
09 Dec - 11 Dec	Avianca
10 Dec - 14 Dec	Avianca
06 Dec - 13 Dec	Avianca
02 Dec - 06 Jan	Avianca
14 Dec - 10 Jan	Avianca
14 Dec - 10 Jan	Copa	direct
30 Dec - 03 Jan	Copa	direct
25 Dec - 07 Jan	Copa	direct
28 Dec - 01 Jan	Copa	direct
14 Dec - 03 Jan	Copa	direct
28 Dec - 25 Jan	Copa	direct
30 Dec - 02 Jan	Copa	direct
28 Dec - 02 Jan	Copa	direct

Also check the deals for one-way flights from Guatemala City to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in December from 211€

Return flights