AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in December 2025 (see full year).

Return flights

01 Dec - 05 Dec	Avianca
01 Dec - 31 Dec	Avianca
10 Dec - 21 Dec	Avianca
10 Dec - 22 Dec	Avianca
15 Dec - 26 Dec	Avianca
15 Dec - 20 Dec	Avianca
18 Dec - 23 Dec	Avianca
12 Dec - 18 Dec	Avianca
04 Dec - 07 Dec	Avianca
15 Dec - 19 Dec	Avianca
22 Dec - 03 Jan	Copa	direct
28 Dec - 03 Jan	Copa	direct
27 Dec - 04 Jan	Copa
20 Dec - 03 Jan	Copa	direct
27 Dec - 04 Jan	Copa	direct

Also check the deals for one-way flights from Guatemala City to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in December from 253€

Return flights