AirHint found the following cheapest return flights from Guatemala City (GUA) to Panama City (PTY) in October 2025 (see full year).

Return flights

22 Oct - 29 Oct	Avianca
13 Oct - 21 Oct	Avianca
14 Oct - 21 Oct	Avianca
21 Oct - 30 Oct	Avianca
01 Oct - 08 Oct	Avianca
30 Oct - 11 Nov	Avianca
14 Oct - 15 Oct	Avianca
20 Oct - 26 Oct	Avianca
13 Oct - 21 Oct	Copa	direct
01 Oct - 08 Oct	Copa	direct
30 Oct - 11 Nov	Copa	direct
20 Oct - 26 Oct	Copa	direct

Also check the deals for one-way flights from Guatemala City to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Panama City in October from 255€

Return flights