AirHint found the following cheapest return flights from Guatemala City (GUA) to Madrid (MAD) in September 2025 (see full year).

Return flights

29 Sep - 07 Oct	Spirit Airlines
29 Sep - 09 Oct	Spirit Airlines
29 Sep - 06 Oct	Spirit Airlines
29 Sep - 04 Oct	Spirit Airlines
19 Sep - 25 Sep	Avianca
30 Sep - 07 Oct	Spirit Airlines
22 Sep - 16 Oct	Spirit Airlines
22 Sep - 07 Oct	Spirit Airlines
28 Sep - 05 Oct	Spirit Airlines
27 Sep - 26 Oct	Avianca
30 Sep - 19 Oct	Spirit Airlines
22 Sep - 30 Sep	Spirit Airlines
22 Sep - 29 Sep	Spirit Airlines
24 Sep - 29 Sep	Alaska Airlines
24 Sep - 30 Sep	Alaska Airlines
23 Sep - 30 Sep	Avianca
21 Sep - 28 Sep	Spirit Airlines
23 Sep - 29 Sep	Spirit Airlines
20 Sep - 30 Sep	Avianca
24 Sep - 28 Sep	Alaska Airlines

Also check the deals for one-way flights from Guatemala City to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Guatemala City to Madrid in September from 646€

Return flights