AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in September 2025 (see full year).

Return flights

06 Sep - 13 Sep	Copa	direct
06 Sep - 19 Sep	Copa	direct
01 Sep - 08 Sep	Copa	direct
15 Sep - 02 Oct	Copa	direct
15 Sep - 18 Sep	Copa	direct
02 Sep - 09 Sep	Copa	direct
02 Sep - 09 Sep	Avianca
03 Sep - 10 Sep	Copa	direct
03 Sep - 10 Sep	Avianca
10 Sep - 17 Sep	Copa	direct
05 Sep - 07 Sep	Copa	direct
29 Sep - 02 Oct	Copa	direct
27 Sep - 04 Oct	Copa	direct
29 Sep - 07 Oct	Copa	direct
30 Sep - 07 Oct	Copa	direct
25 Sep - 02 Oct	Copa	direct
25 Sep - 04 Oct	Copa	direct

Also check the deals for one-way flights from Sao Paulo to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in September from 312€

Return flights