AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in September 2025 (see full year).

Return flights

07 Sep - 15 Sep	Avianca
13 Sep - 20 Sep	Avianca
09 Sep - 16 Sep	Avianca
12 Sep - 21 Sep	Avianca
01 Sep - 08 Sep	Avianca
29 Sep - 07 Oct	Avianca
25 Sep - 02 Oct	Avianca
02 Sep - 07 Sep	Avianca
05 Sep - 09 Sep	Avianca
15 Sep - 25 Sep	Avianca
05 Sep - 12 Sep	Avianca
01 Sep - 08 Sep	Copa	direct
27 Sep - 11 Oct	Copa	direct
29 Sep - 07 Oct	Copa	direct
24 Sep - 01 Oct	Copa	direct
25 Sep - 02 Oct	Copa	direct
29 Sep - 06 Oct	Copa	direct

Also check the deals for one-way flights from Sao Paulo to Panama City in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in September from 389€

Return flights