AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in December 2025 (see full year).

Return flights

18 Dec - 25 Dec	Copa	direct
14 Dec - 18 Dec	Copa	direct
10 Dec - 13 Dec	Avianca
10 Dec - 16 Dec	Avianca
15 Dec - 22 Dec	Copa	direct
15 Dec - 21 Dec	Copa	direct
05 Dec - 08 Dec	Copa	direct
03 Dec - 09 Dec	Copa	direct
04 Dec - 10 Dec	Copa	direct
04 Dec - 11 Dec	Copa	direct
19 Dec - 22 Jan	Copa	direct
22 Dec - 01 Jan	GOL Linhas Aéreas
15 Dec - 13 Jan	Copa	direct
30 Dec - 14 Jan	GOL Linhas Aéreas
25 Dec - 01 Jan	Copa	direct
24 Dec - 01 Jan	Copa	direct
18 Dec - 01 Jan	GOL Linhas Aéreas
24 Dec - 13 Jan	GOL Linhas Aéreas
30 Dec - 14 Jan	Copa	direct
31 Dec - 06 Jan	Copa	direct

Also check the deals for one-way flights from Sao Paulo to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in December from 466€

Return flights