AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in December 2025 (see full year).

Return flights

06 Dec - 15 Dec	Avianca
10 Dec - 14 Dec	Copa	direct
02 Dec - 10 Dec	Copa	direct
18 Dec - 25 Dec	Avianca
15 Dec - 21 Dec	Avianca
31 Dec - 14 Jan	Avianca
12 Dec - 21 Dec	Copa	direct
12 Dec - 21 Dec	Avianca
15 Dec - 21 Dec	Copa	direct
29 Dec - 05 Jan	Avianca
25 Dec - 04 Jan	Avianca
30 Dec - 06 Jan	Avianca
25 Dec - 06 Jan	Avianca
30 Dec - 07 Jan	Avianca
29 Dec - 04 Jan	Avianca
18 Dec - 27 Dec	Avianca
31 Dec - 07 Jan	Avianca
25 Dec - 01 Jan	Avianca
06 Dec - 15 Dec	Copa	direct
25 Dec - 03 Jan	Avianca

Also check the deals for one-way flights from Sao Paulo to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in December from 354€

Return flights