AirHint found the following cheapest return flights from Sao Paulo (GRU) to Panama City (PTY) in December 2025 (see full year).

Return flights

07 Dec - 21 Dec	Avianca
07 Dec - 24 Dec	Avianca
05 Dec - 08 Dec	Avianca
07 Dec - 21 Dec	Copa	direct
07 Dec - 24 Dec	Copa	direct
12 Dec - 21 Dec	Copa	direct
13 Dec - 21 Dec	Copa	direct
05 Dec - 08 Dec	Copa	direct
29 Dec - 14 Jan	Avianca
24 Dec - 08 Jan	Copa	direct
29 Dec - 14 Jan	Copa	direct
25 Dec - 03 Jan	Copa	direct
30 Dec - 04 Jan	Copa	direct
27 Dec - 01 Jan	Copa	direct
26 Dec - 05 Jan	Avianca
26 Dec - 04 Jan	Avianca
28 Dec - 04 Jan	Avianca
27 Dec - 04 Jan	Avianca

Also check the deals for one-way flights from Sao Paulo to Panama City in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Panama City in December from 389€

Return flights