AirHint found the following cheapest return flights from Sao Paulo (GRU) to Istanbul (IST) in September 2025 (see full year).

Return flights

19 Sep - 06 Oct	Turkish Airlines	direct
25 Sep - 15 Oct	Turkish Airlines	direct
23 Sep - 23 Oct	Turkish Airlines	direct
19 Sep - 02 Oct	Turkish Airlines	direct
21 Sep - 01 Oct	Air France
28 Sep - 08 Oct	Turkish Airlines	direct
25 Sep - 02 Oct	Air France
15 Sep - 24 Sep	Avianca
24 Sep - 04 Oct	Air France
22 Sep - 06 Oct	ITA Airways
25 Sep - 02 Oct	Turkish Airlines	direct
23 Sep - 28 Sep	Air France
11 Sep - 20 Sep	KLM
11 Sep - 21 Sep	Avianca
14 Sep - 21 Sep	Avianca
08 Sep - 18 Sep	KLM
10 Sep - 18 Sep	KLM
08 Sep - 15 Sep	KLM
08 Sep - 20 Sep	KLM
08 Sep - 23 Sep	Emirates

Also check the deals for one-way flights from Sao Paulo to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Sao Paulo to Istanbul in September from 848€

Return flights