AirHint found the following cheapest return flights from Sao Paulo (GRU) to Istanbul (IST) in September 2025 (see full year).

Return flights

26 Sep - 06 Oct	Air France
22 Sep - 06 Oct	Air France
26 Sep - 07 Oct	Air France
17 Sep - 30 Sep	Air France
26 Sep - 16 Oct	Air France
30 Sep - 21 Oct	KLM
24 Sep - 30 Sep	TAAG Angola Airlines
25 Sep - 02 Oct	KLM
04 Sep - 10 Sep	TAP
09 Sep - 24 Sep	GOL Linhas Aéreas
25 Sep - 05 Oct	KLM
26 Sep - 11 Oct	Air France
17 Sep - 28 Sep	Air France
03 Sep - 17 Sep	Air France
08 Sep - 20 Sep	LATAM Airlines Group
26 Sep - 03 Oct	KLM
16 Sep - 24 Sep	KLM
21 Sep - 28 Sep	KLM
29 Sep - 12 Oct	Air France
11 Sep - 18 Sep	KLM

Also check the deals for one-way flights from Sao Paulo to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Istanbul

Cheap car rent in Istanbul

Cheapest return flights from Sao Paulo to Istanbul in September from 782€

Return flights