AirHint found the following cheapest return flights from Frankfurt (FRA) to Santiago (SCL) in September 2025 (see full year).

Return flights

18 Sep - 29 Sep	Delta
07 Sep - 29 Sep	Delta
02 Sep - 25 Sep	Delta
01 Sep - 21 Sep	Delta
10 Sep - 24 Sep	Delta
12 Sep - 21 Sep	Delta
12 Sep - 08 Oct	Delta
26 Sep - 18 Oct	Delta
01 Sep - 30 Sep	Delta
11 Sep - 19 Sep	Delta
07 Sep - 06 Oct	Delta
18 Sep - 12 Oct	Delta
15 Sep - 28 Sep	Delta
15 Sep - 21 Sep	Delta
29 Sep - 17 Oct	Delta
24 Sep - 14 Oct	Delta
19 Sep - 05 Oct	Delta
19 Sep - 11 Oct	Delta
30 Sep - 22 Oct	Delta
15 Sep - 02 Oct	Air France

Also check the deals for one-way flights from Frankfurt to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Santiago in September from 803€

Return flights