AirHint found the following cheapest return flights from Frankfurt (FRA) to Santiago (SCL) in September 2025 (see full year).

Return flights

09 Sep - 26 Sep	Delta
16 Sep - 30 Sep	Delta
15 Sep - 28 Sep	Delta
09 Sep - 23 Sep	Delta
15 Sep - 29 Sep	Delta
14 Sep - 09 Oct	Delta
15 Sep - 14 Oct	Delta
09 Sep - 02 Oct	Delta
23 Sep - 14 Oct	Delta
25 Sep - 06 Oct	Delta
14 Sep - 06 Oct	Delta
17 Sep - 19 Oct	Delta
24 Sep - 06 Oct	Delta
23 Sep - 25 Sep	Delta
28 Sep - 05 Oct	Delta
28 Sep - 13 Oct	Delta
13 Sep - 27 Sep	LATAM Airlines Group
23 Sep - 27 Sep	Ryanair
11 Sep - 24 Sep	Delta
18 Sep - 29 Sep	Air France

Also check the deals for one-way flights from Frankfurt to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Frankfurt to Santiago in September from 802€

Return flights