AirHint found the following cheapest return flights from Florence (FLR) to Istanbul (IST) in September 2025 (see full year).

Return flights

19 Sep - 22 Sep	Volotea
20 Sep - 27 Sep	Volotea
18 Sep - 21 Sep	Vueling Airlines
04 Sep - 11 Sep	KLM
04 Sep - 10 Sep	KLM
23 Sep - 26 Sep	Vueling Airlines
06 Sep - 10 Sep	Volotea
02 Sep - 04 Sep	Volotea
01 Sep - 08 Sep	Air France
03 Sep - 05 Sep	Volotea
24 Sep - 02 Oct	Vueling Airlines
24 Sep - 11 Oct	Vueling Airlines
24 Sep - 03 Oct	Vueling Airlines
24 Sep - 10 Oct	Vueling Airlines
24 Sep - 15 Oct	Vueling Airlines
19 Sep - 02 Oct	Vueling Airlines
24 Sep - 05 Oct	Vueling Airlines
19 Sep - 03 Oct	Vueling Airlines
19 Sep - 10 Oct	Vueling Airlines
24 Sep - 09 Oct	Vueling Airlines

Also check the deals for one-way flights from Florence to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Florence to Istanbul in September from 197€

Return flights