AirHint found the following cheapest return flights from Florence (FLR) to Istanbul (IST) in September 2025 (see full year).

Return flights

26 Sep - 14 Oct	Volotea
24 Sep - 30 Sep	Vueling Airlines
20 Sep - 23 Sep	Volotea
19 Sep - 22 Sep	Volotea
20 Sep - 22 Sep	Volotea
23 Sep - 27 Sep	Vueling Airlines
18 Sep - 23 Sep	Vueling Airlines
19 Sep - 23 Sep	Volotea
18 Sep - 22 Sep	Vueling Airlines
23 Sep - 29 Sep	Vueling Airlines
17 Sep - 22 Sep	Volotea
30 Sep - 10 Oct	Vueling Airlines
27 Sep - 13 Oct	Volotea
28 Sep - 04 Oct	Volotea
28 Sep - 05 Oct	Vueling Airlines
24 Sep - 14 Oct	Vueling Airlines
26 Sep - 16 Oct	Vueling Airlines
26 Sep - 15 Oct	Vueling Airlines
26 Sep - 13 Oct	Vueling Airlines
26 Sep - 08 Oct	Vueling Airlines

Also check the deals for one-way flights from Florence to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Florence to Istanbul in September from 201€

Return flights