AirHint found the following cheapest return flights from Rome (FCO) to Santiago (SCL) in September 2025 (see full year).

Return flights

03 Sep - 24 Sep	Delta
03 Sep - 26 Sep	Delta
10 Sep - 01 Oct	Ryanair
23 Sep - 06 Oct	Delta
25 Sep - 07 Oct	Delta
16 Sep - 16 Oct	Delta
10 Sep - 17 Sep	Wizz Air Malta
08 Sep - 14 Sep	Ryanair
13 Sep - 23 Sep	Air France
01 Sep - 14 Sep	Delta
28 Sep - 05 Oct	Delta
06 Sep - 15 Sep	Ryanair
19 Sep - 26 Sep	Ryanair
19 Sep - 29 Sep	Delta
07 Sep - 20 Sep	LATAM Airlines Group
29 Sep - 03 Oct	Delta

Also check the deals for one-way flights from Rome to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in September from 715€

Return flights