AirHint found the following cheapest return flights from Rome (FCO) to Santiago (SCL) in December 2025 (see full year).

Return flights

01 Dec - 05 Dec	Delta
01 Dec - 11 Dec	Air France
30 Dec - 25 Jan	Iberia
01 Dec - 21 Dec	Iberia
23 Dec - 15 Jan	Delta
05 Dec - 10 Dec	LATAM Airlines Group
10 Dec - 13 Jan	Delta
01 Dec - 14 Jan	Delta
12 Dec - 28 Jan	Delta
27 Dec - 17 Jan	Delta
15 Dec - 12 Jan	Norse Atlantic Airways
24 Dec - 11 Jan	Delta
12 Dec - 12 Jan	Norse Atlantic Airways
12 Dec - 30 Dec	Iberia
23 Dec - 30 Dec	Delta
29 Dec - 16 Jan	Delta
16 Dec - 31 Dec	Air Canada
22 Dec - 31 Dec	Air Canada
05 Dec - 15 Dec	Iberia
09 Dec - 31 Dec	Delta

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

Book a cheap hotel in Santiago

Cheap car rent in Santiago

Cheapest return flights from Rome to Santiago in December from 774€

Return flights