AirHint found the following cheapest return flights from Rome (FCO) to Santiago (SCL) in December 2025 (see full year).

Return flights

08 Dec - 22 Jan	Delta
01 Dec - 07 Dec	Turkish Airlines
01 Dec - 09 Dec	Turkish Airlines
05 Dec - 12 Dec	Turkish Airlines
01 Dec - 10 Dec	SWISS
24 Dec - 16 Jan	Delta
08 Dec - 14 Jan	Delta
08 Dec - 11 Dec	Turkish Airlines
03 Dec - 10 Dec	Ryanair
08 Dec - 15 Jan	Delta
05 Dec - 14 Dec	Delta
04 Dec - 15 Dec	Delta
07 Dec - 14 Dec	Delta
24 Dec - 13 Jan	Delta
26 Dec - 14 Jan	Delta
29 Dec - 21 Jan	Delta
29 Dec - 20 Jan	Delta
29 Dec - 18 Jan	Delta
28 Dec - 21 Jan	Delta
15 Dec - 29 Dec	Norse Atlantic Airways

Also check the deals for one-way flights from Rome to Santiago in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in December from 716€

Return flights