AirHint found the following cheapest return flights from Rome (FCO) to Santiago (SCL) in October 2025 (see full year).

Return flights

09 Oct - 22 Oct	Delta
07 Oct - 22 Oct	Delta
07 Oct - 24 Nov	Delta
09 Oct - 19 Oct	Delta
28 Oct - 23 Nov	Delta
23 Oct - 08 Nov	Delta
24 Oct - 08 Nov	Condor
02 Oct - 05 Oct	Ryanair
27 Oct - 10 Nov	Ryanair
27 Oct - 22 Nov	Ryanair
26 Oct - 02 Nov	Ryanair
15 Oct - 26 Oct	TAP
28 Oct - 12 Nov	Royal Air Maroc
19 Oct - 26 Oct	Aeroitalia
10 Oct - 13 Oct	Norse Atlantic Airways
31 Oct - 07 Nov	Ryanair
24 Oct - 09 Nov	Condor
03 Oct - 18 Oct	Wizz Air Malta
05 Oct - 10 Oct	Ryanair
19 Oct - 31 Oct	Aeroitalia

Also check the deals for one-way flights from Rome to Santiago in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Rome to Santiago in October from 714€

Return flights