AirHint found the following cheapest return flights from Detroit (DTW) to Cairo (CAI) in October 2025 (see full year).

Return flights

14 Oct - 23 Oct	Royal Jordanian
09 Oct - 16 Oct	Royal Jordanian
03 Oct - 16 Oct	Royal Jordanian
21 Oct - 28 Oct	Royal Jordanian
05 Oct - 07 Nov	Royal Jordanian
05 Oct - 09 Nov	Royal Jordanian
02 Oct - 08 Oct	Royal Jordanian
18 Oct - 01 Nov	jetBlue
25 Oct - 04 Nov	Delta
13 Oct - 19 Nov	Spirit Airlines
03 Oct - 10 Oct	KLM
06 Oct - 10 Nov	Air France
01 Oct - 04 Nov	Spirit Airlines
01 Oct - 08 Oct	Spirit Airlines
05 Oct - 17 Oct	Air France
08 Oct - 22 Oct	Air France
13 Oct - 16 Oct	Air France

Also check the deals for one-way flights from Detroit to Cairo in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Detroit to Cairo in October from $574

Return flights