AirHint found the following cheapest return flights from Cancun (CUN) to Santiago (SCL) in September 2025 (see full year).

Return flights

10 Sep - 27 Sep	Sky Airline
09 Sep - 25 Sep	Sky Airline
02 Sep - 09 Sep	Sky Airline
25 Sep - 09 Oct	Sky Airline
25 Sep - 11 Oct	Sky Airline
24 Sep - 02 Oct	Sky Airline
02 Sep - 23 Sep	Copa
04 Sep - 25 Sep	Copa
30 Sep - 09 Oct	Sky Airline
14 Sep - 12 Oct	Sky Airline
14 Sep - 21 Sep	Sky Airline
11 Sep - 20 Sep	Copa
24 Sep - 01 Oct	Avianca
02 Sep - 16 Sep	Sky Airline
13 Sep - 20 Sep	Sky Airline
09 Sep - 17 Sep	Sky Airline
10 Sep - 01 Oct	Sky Airline
25 Sep - 07 Oct	Sky Airline
25 Sep - 02 Oct	Sky Airline
30 Sep - 10 Oct	Arajet

Also check the deals for one-way flights from Cancun to Santiago in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cancun to Santiago in September from 321€

Return flights