AirHint found the following cheapest return flights from Cape Town (CPT) to Istanbul (IST) in September 2025 (see full year).

Return flights

14 Sep - 22 Sep	Qatar Airways
09 Sep - 16 Sep	KLM
08 Sep - 22 Sep	Qatar Airways
09 Sep - 23 Sep	KLM
08 Sep - 15 Sep	Qatar Airways
02 Sep - 16 Sep	Qatar Airways
03 Sep - 16 Sep	Qatar Airways
02 Sep - 07 Sep	Qatar Airways
01 Sep - 14 Sep	Qatar Airways
11 Sep - 25 Sep	Qatar Airways
19 Sep - 05 Oct	Qatar Airways
01 Sep - 01 Oct	KLM
23 Sep - 05 Oct	Qatar Airways
19 Sep - 05 Oct	Turkish Airlines	direct
23 Sep - 05 Oct	Turkish Airlines	direct

Also check the deals for one-way flights from Cape Town to Istanbul in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cape Town to Istanbul in September from 506€

Return flights