AirHint found the following cheapest return flights from Cali (CLO) to Madrid (MAD) in September 2025 (see full year).

Return flights

28 Sep - 18 Oct	Spirit Airlines
23 Sep - 30 Sep	JetSmart
20 Sep - 25 Oct	Spirit Airlines
26 Sep - 08 Oct	Spirit Airlines
12 Sep - 29 Sep	JetSmart
28 Sep - 19 Oct	Spirit Airlines
06 Sep - 11 Sep	Spirit Airlines
06 Sep - 12 Sep	Spirit Airlines
24 Sep - 01 Oct	JetSmart
30 Sep - 16 Oct	JetSmart
28 Sep - 05 Oct	Spirit Airlines
21 Sep - 26 Oct	Spirit Airlines
13 Sep - 20 Sep	Spirit Airlines
16 Sep - 29 Sep	Avianca
26 Sep - 29 Sep	Avianca
04 Sep - 12 Sep	Spirit Airlines
09 Sep - 17 Sep	Avianca
11 Sep - 20 Sep	Spirit Airlines
24 Sep - 14 Oct	Avianca
26 Sep - 10 Oct	Spirit Airlines

Also check the deals for one-way flights from Cali to Madrid in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cali to Madrid in September from 715€

Return flights