AirHint found the following cheapest return flights from Cali (CLO) to Madrid (MAD) in December 2025 (see full year).

Return flights

16 Dec - 01 Jan	WORLD2FLY	direct
14 Dec - 01 Jan	WORLD2FLY	direct
16 Dec - 14 Jan	WORLD2FLY
14 Dec - 14 Jan	WORLD2FLY
10 Dec - 24 Jan	WORLD2FLY
11 Dec - 21 Jan	Avianca
14 Dec - 25 Jan	Avianca
10 Dec - 21 Jan	Avianca
11 Dec - 31 Jan	Avianca
14 Dec - 22 Jan	Avianca
01 Dec - 10 Dec	JetSmart
15 Dec - 31 Dec	Avianca
23 Dec - 31 Dec	Avianca
10 Dec - 31 Dec	Avianca
14 Dec - 30 Dec	WORLD2FLY
16 Dec - 30 Dec	WORLD2FLY
16 Dec - 29 Dec	WORLD2FLY
11 Dec - 30 Dec	LATAM Airlines Group
24 Dec - 31 Dec	Avianca
01 Dec - 14 Dec	LATAM Airlines Group

Also check the deals for one-way flights from Cali to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Cali to Madrid in December from 644€

Return flights