AirHint found the following cheapest return flights from Amsterdam (AMS) to Panama City (PTY) in October 2025 (see full year).

Return flights

02 Oct - 11 Oct	Air France
31 Oct - 07 Nov	Lufthansa
14 Oct - 26 Oct	United
26 Oct - 10 Nov	Lufthansa
20 Oct - 02 Nov	United
22 Oct - 05 Nov	United
01 Oct - 07 Oct	United
01 Oct - 22 Oct	United
17 Oct - 26 Oct	United
01 Oct - 11 Oct	United
17 Oct - 24 Oct	United
19 Oct - 23 Oct	Delta
11 Oct - 01 Nov	Delta
17 Oct - 01 Nov	Delta
20 Oct - 02 Nov	KLM	direct
22 Oct - 05 Nov	KLM	direct
01 Oct - 07 Oct	KLM	direct
01 Oct - 22 Oct	KLM	direct
31 Oct - 07 Nov	KLM	direct

Also check the deals for one-way flights from Amsterdam to Panama City in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest return flights from Amsterdam to Panama City in October from 649€

Return flights