AirHint found the following cheapest one-way flights from Santa Cruz (VVI) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

23 Dec	Air Europa	direct
25 Dec	Air Europa	direct
13 Dec	Air Europa	direct
20 Dec	Air Europa	direct
09 Dec	Air Europa	direct
01 Dec	Boliviana de Aviacion	direct
08 Dec	Boliviana de Aviacion	direct
12 Dec	Boliviana de Aviacion
24 Dec	Avianca
19 Dec	Avianca

Also check the deals for return flights from Santa Cruz to Madrid in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Santa Cruz to Madrid in December from 389€

One-Way flights