Cheapest one-way flights from Santa Cruz to Madrid in December from 350€

AirHint found the following cheapest one-way flights from Santa Cruz (VVI) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

23 Dec Air Europa direct
22 Dec Air Europa direct
02 Dec LATAM Airlines Group
05 Dec GOL Linhas Aéreas
06 Dec Boliviana de Aviacion
06 Dec Air Europa direct
10 Dec Avianca
18 Dec Air Europa direct
13 Dec Boliviana de Aviacion direct
04 Dec Air Europa direct

Also check the deals for return flights from Santa Cruz to Madrid in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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