Cheapest one-way flights from Santa Cruz to Madrid in December from 428€

AirHint found the following cheapest one-way flights from Santa Cruz (VVI) to Madrid (MAD) in December 2025 (see full year).

One-Way flights

09 Dec Boliviana de Aviacion direct
07 Dec Boliviana de Aviacion direct
23 Dec Air Europa direct
15 Dec Boliviana de Aviacion direct
18 Dec Boliviana de Aviacion direct
21 Dec Iberia direct
16 Dec Iberia direct
12 Dec Boliviana de Aviacion
25 Dec Air Europa direct
29 Dec Air Europa direct

Also check the deals for return flights from Santa Cruz to Madrid in December.

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The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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