AirHint found the following cheapest one-way flights from Santa Cruz (VVI) to Madrid (MAD) in October 2025 (see full year).

One-Way flights

18 Oct	Boliviana de Aviacion	direct
30 Oct	Boliviana de Aviacion	direct
28 Oct	Air Europa	direct
23 Oct	Air Europa	direct
21 Oct	Avianca
13 Oct	Boliviana de Aviacion
06 Oct	Avianca
07 Oct	Boliviana de Aviacion
21 Oct	Air Europa	direct
20 Oct	Avianca

Also check the deals for return flights from Santa Cruz to Madrid in October.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Santa Cruz to Madrid in October from 423€

One-Way flights