AirHint found the following cheapest one-way flights from Santiago (SCL) to Mendoza (MDZ) in December 2025 (see full year).

One-Way flights

27 Dec	JetSmart	direct
26 Dec	JetSmart	direct
01 Dec	JetSmart	direct
19 Dec	JetSmart	direct
12 Dec	JetSmart	direct
13 Dec	JetSmart	direct
14 Dec	LATAM Airlines Group	direct
09 Dec	LATAM Airlines Group	direct
25 Dec	Sky Airline	direct
15 Dec	Sky Airline	direct

Also check the deals for return flights from Santiago to Mendoza in December.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Santiago to Mendoza in December from 36€

One-Way flights