Cheapest one-way flights from Santiago to Guayaquil in December from 254€

AirHint found the following cheapest one-way flights from Santiago (SCL) to Guayaquil (GYE) in December 2025 (see full year).

One-Way flights

23 Dec Copa
15 Dec Copa

Also check the deals for return flights from Santiago to Guayaquil in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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