AirHint found the following cheapest one-way flights from Rome (ROM) to Lisbon (LIS) in September 2025 (see full year).

One-Way flights

26 Sep	Ryanair
30 Sep	Vueling Airlines
22 Sep	Ryanair
29 Sep	Ryanair
19 Sep	Ryanair
20 Sep	Ryanair	direct
30 Sep	Wizz Air Malta	direct
17 Sep	Wizz Air Malta	direct
18 Sep	Wizz Air Malta	direct
16 Sep	Wizz Air Malta

Also check the deals for return flights from Rome to Lisbon in September.

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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Cheapest one-way flights from Rome to Lisbon in September from 52€

One-Way flights