Cheapest one-way flights from Chicago to Santiago in December from 255€

AirHint found the following cheapest one-way flights from Chicago (ORD) to Santiago (SCL) in December 2025 (see full year).

One-Way flights

10 Dec Spirit Airlines
06 Dec Spirit Airlines
03 Dec Spirit Airlines
07 Dec Spirit Airlines
04 Dec Spirit Airlines
02 Dec Spirit Airlines
15 Dec Spirit Airlines
21 Dec LATAM Airlines Group
13 Dec Avianca
23 Dec Delta

Also check the deals for return flights from Chicago to Santiago in December.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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