Cheapest one-way flights from Chicago to Santiago in October from 228€

AirHint found the following cheapest one-way flights from Chicago (ORD) to Santiago (SCL) in October 2025 (see full year).

One-Way flights

05 Oct Spirit Airlines

Also check the deals for return flights from Chicago to Santiago in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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