Cheapest one-way flights from Chicago to Santiago in October from 279€

AirHint found the following cheapest one-way flights from Chicago (ORD) to Santiago (SCL) in October 2025 (see full year).

One-Way flights

07 Oct Avianca
20 Oct Avianca

Also check the deals for return flights from Chicago to Santiago in October.

Skyscanner

The deals are updated regularly. The prices may go up as tickets are purchased by other travellers. Only the cheapest flights are offered. Select a price to book and secure these cheap prices.

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